Key result
Plasma PDGF levels and plaque gray scale median link to carotid bulb IMT progression.
Why the study?
Factors that influence the atherosclerotic disease process in high-risk individuals remain poorly understood.
Cohort (n=865)
Effect estimate: Standardized β 0.20 (95% CI 0.03-0.07)
p-value: p=< 0.001
Progression of carotid atherosclerosis in high-risk patients primarily occurs in fibrotic plaques and is associated with increased levels of platelet-derived growth factor (PDGF).
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PDGF associates with carotid IMT progression in high-risk patients; hypothesis-generating and leaves open causal or therapeutic implications.
Khan et al. (2022) conducted a cohort in Carotid atherosclerosis (n=865). Plasma PDGF, plaque GSM, and baseline bulb IMT was evaluated on Progression of bulb intima-media thickness (IMT) (Standardized β 0.20, 95% CI 0.03-0.07, p=< 0.001). Progression of carotid bulb intima-media thickness over 3 years was independently associated with plasma PDGF levels (Standardized β 0.20; 95% CI 0.03-0.07; p<0.001) and plaque gray scale median.
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