September 2, 2022International Journal of Molecular Sciences45 citationsOpen Access
Molecular Pathways in Pulmonary Arterial Hypertension
Key Result
A review of the molecular pathogenesis of pulmonary arterial hypertension highlights the need for novel treatments targeting genetic pathways to improve upon the modest benefits of current therapies.
Structured PICO
P
Population
Patients with pulmonary arterial hypertension
This review highlights the molecular pathogenesis of pulmonary arterial hypertension and emphasizes the need for ongoing research to discover new treatments targeting novel genetic pathways.
Abstract
Pulmonary arterial hypertension is a multifactorial, chronic disease process that leads to pulmonary arterial endothelial dysfunction and smooth muscular hypertrophy, resulting in impaired pliability and hemodynamics of the pulmonary vascular system, and consequent right ventricular dysfunction. Existing treatments target limited pathways with only modest improvement in disease morbidity, and little or no improvement in mortality. Ongoing research has focused on the molecular basis of pulmonary arterial hypertension and is going to be important in the discovery of new treatments and genetic pathways involved. This review focuses on the molecular pathogenesis of pulmonary arterial hypertension.