Key result
In patients with mild mitral stenosis, atrial filling volume was significantly augmented to 23 ml/M2 compared to 9 ml/M2 in normal subjects, compensating for decreased early diastolic filling.
Why the study?
How does surgical treatment affect left ventricular filling dynamics in patients with mitral stenosis?
Observational (n=39)
Yes
How does surgical treatment affect left ventricular filling dynamics in patients with mitral stenosis?
Absolute Event Rate: 23% vs 9%
p-value: p=<0.001
Echocardiographic evaluation reveals that altered left atrial transport function plays a crucial role in left ventricular filling in mitral stenosis, with impaired atrial contraction evident in severe cases even after surgery.
Augmented atrial filling supports LV compensation in mild mitral stenosis; leaves open effects of surgery on left atrial transport in severe disease.
Echocardiographic evaluation of left ventricular volume change during rapid and atrial filling periods was made in patients with mital stenosis. The significant reduction of rapid filling volume was observed and the rate of rapid filling was approximately the half of normal in mitral stenosis. The rapid filling period showed a good correlation to the mitral valve area measured at operation. After surgical treatment, the rate of rapid filling was significantly increased but was still significantly smaller than normal. It was suggested that the remained structural abnormality of mitral apparatus depressed the inflow through the mitral valve in early diastole despite successful mitral valvotomy. Left ventricular filling during atrial contraction (atrial filling) was augmented twice as much as normal in patients with milder mitral stenosis, compensating the decreased early diastolic filling. In contrast, the atrial filling did not increase in severe mitral stenosis, resulting in the decreased cardiac output. Following mitral commissurotomy, the atrial filling in milder mitral stenosis was reduced but remained significantly larger than normal. There was no change of atrial filling in severe mitral stenosis postoperatively. This fact suggested the existence of impaired contraction of left atrium in cases with severe mitral stenosis. Our results show that the altered left atrial transport function plays an important role in the left ventricular filling in mitral stenosis.
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Yamaguchi et al. (1978) conducted an observational in Mitral Stenosis (n=39). Mitral stenosis vs. Normal subjects was evaluated on Atrial filling volume (AFV) in mild mitral stenosis (p=<0.001). In patients with mild mitral stenosis, atrial filling volume was significantly augmented to 23 ml/M2 compared to 9 ml/M2 in normal subjects, compensating for decreased early diastolic filling.
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