The stomach in health and disease
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Overview
State-of-the-art review demonstrates complex gastric endocrine and immune functions in humans, indicating eradication of Helicobacter pylori protects long-term gastrointestinal health.
Key Points
- To review the multifaceted physiological, endocrine, immunological, and microbiological roles of the stomach in maintaining health and driving gastrointestinal disease.
- State-of-the-art narrative synthesis evaluating literature on gastric physiology, motility, and the gastric microenvironment.
- Review of clinical and pathological mechanisms linking Helicobacter pylori infection to gastritis, peptic ulcer disease, and gastric adenocarcinoma.
- Gastric acid production is critical for initiating digestion and providing a primary antimicrobial barrier against ingested pathogens.
- Helicobacter pylori infection represents the primary chronic driver disrupting gastric mucosal architecture, causing most peptic ulcers and gastric cancers.
- Gastric neuromuscular dysmotility and alterations in the gastric microbiome substantially underpin functional dyspepsia, gastroparesis, and appetite dysregulation.
Cite This Study
Hunt et al. (2015) studied this question.