Key result
Reduced cardiac parasympathetic activity promotes cardiorespiratory disease, making its restoration a key therapeutic target.
Why the study?
Autonomic imbalance, specifically reduced parasympathetic activity to the heart, generates and maintains many cardiorespiratory diseases, warranting a review of translational targets to restore parasympathetic activity.
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Design
Review
Answers are grounded in this paper and cite their sources.
Supports parasympathetic restoration as a therapeutic target; hypothesis-generating and should not change practice without prospective trials.
In this review we will briefly summarize the evidence that autonomic imbalance, more specifically reduced parasympathetic activity to the heart, generates and/or maintains many cardiorespiratory diseases and will discuss mechanisms and sites, from myocytes to the brain, that are potential translational targets for restoring parasympathetic activity and improving cardiorespiratory health.
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Kay et al. (2021) studied this question. Reduced parasympathetic activity to the heart generates and maintains cardiorespiratory diseases, making its restoration a target for improving health.
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