Why the study?
Does acetylcholine affect automaticity and conduction in the His-Purkinje system of the dog?
Does acetylcholine affect automaticity and conduction in the His-Purkinje system of the dog?
Acetylcholine decreases automaticity and increases conduction velocity in the canine His-Purkinje system.
Does not support clinical use; leaves open human studies of cholinergic modulation in ventricular conduction.
Conventional intracellular recordings from the bundle of His and right bundle branch of the canine heart demonstrated that the slope of diastolic depolarization is markedly depressed by superfusion with relatively small concentrations (4-8 µg/ml) of acetylcholine. As the cells become less automatic, take-off potential increases, rise time of phase 0 is reduced, action potential amplitude increases, and conduction proceeds more rapidly.
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Bailey et al. (1972) studied this question.
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