What question did this study set out to answer?

To examine whether cord blood appetite hormone levels are associated with early-life growth trajectories and childhood adiposity at 4 to 6 years of age.

November 6, 2025JAMA Network OpenOpen Access

Cord Blood Appetite Hormones and Early-Life Growth and Childhood Adiposity in the ENVIRONAGE Cohort

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Authors

TRThaïs De RuyterGhent University NMNathalie MichelsGhent University Hospital RARossella AlfanoHasselt University

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Implication

Prospective cohort study reveals cord blood appetite hormones associate with rapid growth and adiposity in young children, suggesting birth-stage hormonal pathways influence body composition.

Key Points

To examine whether cord blood appetite hormone levels are associated with early-life growth trajectories and childhood adiposity at 4 to 6 years of age.
Prospective birth cohort study within the ENVIRONAGE cohort in Belgium, recruiting participants between January 1, 2010, and December 31, 2016, with follow-up at 4 to 6 years of age (N=325; median age 4.49 years).
Cord blood levels of GLP-1, PYY, PP, and leptin were analyzed in subgroups based on sample availability (PP and leptin, n=226; PYY and GLP-1, n=229).
Outcomes included adiposity peak, rapid or slow growth at 6, 12, and 24 months, and waist-to-height ratio along with BMI z scores at 4 to 6 years.
Cord blood PYY and PP levels were associated with an increased risk of rapid growth in the first 2 years of life (OR 1.71; 95% CI, 1.03-2.84 and OR 1.65; 95% CI, 1.21-2.27, respectively), whereas leptin was inversely associated (OR 0.43; 95% CI, 0.27-0.66).
Cord blood PYY levels were positively associated with the adiposity peak (β = 0.14; 95% CI, 0.01-0.27).
Cord blood PYY and PP levels were associated with a higher BMI z score at 4 to 6 years of age (β = 0.16; 95% CI, 0.04-0.30 and β = 0.17; 95% CI, 0.004-0.34, respectively).

Cite This Study

Ruyter et al. (2025) studied this question.

synapsesocial.com/papers/6a0f6e3a8090e499da5fc727 https://doi.org/10.1001/jamanetworkopen.2025.42140

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Implication

Prospective cohort study reveals cord blood appetite hormones associate with rapid growth and adiposity in young children, suggesting birth-stage hormonal pathways influence body composition.

Cord Blood Appetite Hormones and Early-Life Growth and Childhood Adiposity in the ENVIRONAGE Cohort

Discussion

Member takes

Implication

Key Points

Cite This Study

Cord Blood Appetite Hormones and Early-Life Growth and Childhood Adiposity in the ENVIRONAGE Cohort

Discussion

Member takes

Implication

Key Points

Cite This Study

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