What question did this study set out to answer?

To define lobular neoplasia as a distinct clinical-pathological entity and evaluate risk factors associated with subsequent development of invasive breast carcinoma.

August 1, 1978Cancer

Lobular neoplasia (so-called lobular carcinoma in situ) of the breast

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Authors

CHC. D. HaagensenBarnes-Jewish Hospital NLNathan LaneNewYork–Presbyterian Hospital RLRaffaele LattesAmerican Cancer Society

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Implication

Cohort study observes a 17.1% breast carcinoma risk in women with lobular neoplasia, suggesting close clinical follow-up rather than mastectomy.

Key Points

To define lobular neoplasia as a distinct clinical-pathological entity and evaluate risk factors associated with subsequent development of invasive breast carcinoma.
Reviewed and reclassified 5,560 benign epithelial breast lesions to identify 211 cases of isolated lobular neoplasia lacking co-existing infiltrating carcinoma.
Tracked patient age, affected breast, follow-up duration, microscopic variations, family history of breast carcinoma, and the presence of gross cystic disease.
Calculated observed-to-expected ratios for subsequent carcinoma based on combinations of predisposing clinical risk factors.
Frank carcinoma developed in 17.1% of patients during follow-up, with qualitative and quantitative microscopic variations showing no predictive value for future malignancy.
Predisposing risk factors acted cumulatively, producing an observed-to-expected carcinoma ratio of 13:8 when lobular neoplasia, gross cystic disease, and family history were all present.
Routine management via systematic physical breast palpation every four months is recommended over mastectomy.

Cite This Study

Haagensen et al. (1978) studied this question.

synapsesocial.com/papers/6a0f6ec32badbc352afe298b https://doi.org/10.1002/1097-0142(197808)42:2<737::aid-cncr2820420247>3.0.co;2-t

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Implication

Cohort study observes a 17.1% breast carcinoma risk in women with lobular neoplasia, suggesting close clinical follow-up rather than mastectomy.

Lobular neoplasia (so-called lobular carcinoma in situ) of the breast

Discussion

Member takes

Implication

Key Points

Cite This Study

Lobular neoplasia (so-called lobular carcinoma in situ) of the breast

Discussion

Member takes

Implication

Key Points

Cite This Study

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