Why might South Asians be so susceptible to central obesity and its atherogenic consequences? The adipose tissue overflow hypothesis
Key result
The adipose tissue overflow hypothesis proposes that South Asians have a smaller superficial subcutaneous adipose tissue compartment than whites, leading to earlier metabolic complications of obesity.
Population
South Asians and whites (theoretical population for hypothesis)
Design
Review
Authors
Discussion
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Implication
May inform ethnicity-specific cardiometabolic risk assessment; leaves open prospective validation of compartment-specific fat distribution.
Structured PICO
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Population
South Asians and whites (theoretical population for hypothesis)
The adipose tissue overflow hypothesis provides a theoretical framework for understanding the increased susceptibility of South Asians to central obesity, atherogenic dyslipidemia, and coronary disease.
Cite This Study
Sniderman et al. (2007) conducted a review in Central obesity and atherogenic consequences in South Asians. The adipose tissue overflow hypothesis proposes that South Asians have a smaller superficial subcutaneous adipose tissue compartment than whites, leading to earlier metabolic complications of obesity.