Key result
Ongoing post-COVID cardiac symptoms are linked to a ~6% MACE rate and reduced myocardial strain.
Why the study?
Data on long-term cardiac involvement and clinical outcomes in patients with persistent cardiac symptoms following SARS-CoV-2 infection remain limited.
Does the post-COVID-19 condition with persistent cardiac symptoms associate with myocardial abnormalities on CMR and increased risk of MACE compared to controls?
Population
94 post-COVID-19 patients with ongoing cardiac symptoms and 100 controls
Comparison
Post-COVID-19 patients vs controls
Design
Observational cohort study
Follow-up
Median of 269 days (IQR 144–352)
Authors
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May warrant closer surveillance in symptomatic post-COVID patients; leaves open whether CMR findings predict or modify MACE risk.
Cohort (n=194)
Does the post-COVID-19 condition with persistent cardiac symptoms associate with myocardial abnormalities on CMR and increased risk of MACE compared to controls?
Absolute Event Rate: 0.063% vs 0%
p-value: p=0.029
Patients with persistent cardiac symptoms post-COVID-19 exhibit subclinical myocardial dysfunction on CMR and a higher rate of adverse cardiac events compared to controls.
Georgiadis et al. (2025) conducted a cohort in Post-COVID-19 condition (n=194). Post-COVID-19 condition vs. Controls was evaluated on Major adverse cardiac events (MACEs) (p=0.029). Patients with ongoing cardiac symptoms post-COVID-19 exhibited a higher rate of major adverse cardiac events compared to controls (0.063 vs. 0; p=0.029) and reduced myocardial strain.
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