Key result
A non-linear end-systolic pressure-volume index non-invasively segregates clinical HF groups.
Why the study?
Does the mathematical index (Pisom - Pm)/Pm segregate between different clinical groups and provide insight into HFpEF?
Does the mathematical index (Pisom - Pm)/Pm segregate between different clinical groups and provide insight into HFpEF?
A novel mathematical index based on the end-systolic pressure-volume relation may help segregate clinical groups and provide new insights into the pathophysiology of HFpEF.
A mathematical formalism for the non-linear endsystolic pressure-volume relation (ESPVR) in the heart ventricles has the interesting feature that the peak active pressure generated by the myocardium (also called peak isovolumic pressure Pisom by physiologists) is included in the mathematical formalism describing the ESPVR. In this study we look at the ratio (Pisom -Pm)/Pm as an index to segregate between different clinical groups, this ratio can be calculated in a non-invasive way with the mathematical model used. Application to the left ventricle by using clinical data taken from the medical literature is given and discussed. Mathematical relations between the ejection fraction (EF) and the parameters describing the ESPVR are used in a way to get new insight into the problem of heart failure with normal or preserved ejection fraction (HFpEF).
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Rachad M. Shoucri (2016) studied Heart failure. Mathematical model of ESPVR index (Pisom - Pm)/Pm was evaluated on Segregation of clinical groups based on ventricular performance. The mathematical index (Pisom - Pm)/Pm, derived from the non-linear end-systolic pressure-volume relation, can be used to non-invasively segregate different clinical groups of heart failure.
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