Key result
Mathematical modeling of the end-systolic pressure-volume relation provides consistent insights into the mechanics of ventricular contraction in heart failure with preserved ejection fraction.
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Mathematical relations between ejection fraction and end-systolic pressure-volume relation parameters can provide better insight into the mechanics of ventricular contraction in HFpEF.
The problem of heart failure with normal or preserved ejection fraction (HFpEF) has been the subject of numerous studies. Mathematical relations between ejection fraction (EF) and the parameters describing linear and non-linear end-systolic pressure-volume relation (ESPVR) have been derived in previous publications. Consequently one can expect a link between observed percentage of heart failure and EF on the one hand, and indexes derived from the ESPVR on the other hand, which is the subject of this study. It is shown that important information can be derived from the ESPVR that can give better insight into the mechanics of ventricular contraction. Applications to clinical data published in the literature show the consistency of the mathematical formalism used.
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Rachad M. Shoucri (2015) studied Heart failure with preserved ejection fraction (HFpEF). Mathematical modeling of end-systolic pressure-volume relation (ESPVR) was evaluated on Link between observed percentage of heart failure and EF, and indexes derived from ESPVR. Mathematical modeling of the end-systolic pressure-volume relation provides consistent insights into the mechanics of ventricular contraction in heart failure with preserved ejection fraction.
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