Key result
PCI-induced plaque disruption is linked to a ~44% increase in LBP, a novel plaque rupture biomarker.
Why the study?
Does a workflow combining plaque imaging and proteomics identify biomarkers of human coronary atherosclerotic plaque disruption?
Population
Humans undergoing angioplasty-induced plaque disruption
Comparison
Plaque imaging combined with plaque and plasma… vs Corresponding control samples
Design
Other
Follow-up
5 minutes post-disruption
Authors
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LBP rise may flag plaque rupture during PCI; extends OCT-proteomics workflows for coronary biomarker discovery.
Observational (n=81)
No
Does a workflow combining plaque imaging and proteomics identify biomarkers of human coronary atherosclerotic plaque disruption?
Effect estimate: 1.44 times increase (95% CI 1.07-1.81)
p-value: p=0.0159
A novel workflow integrating optical coherence tomography and proteomics identified new biomarkers, including MMP9 and five novel proteins, associated with human coronary plaque disruption.
Lee et al. (2017) conducted an observational in Coronary atherosclerosis (n=81). Percutaneous coronary intervention (PCI) vs. Diagnostic angiography without stenting was evaluated on Plasma lipopolysaccharide binding protein (LBP) levels (1.44 times increase, 95% CI 1.07-1.81, p=0.0159). Percutaneous coronary intervention-induced plaque disruption led to a 1.44-fold increase in systemic lipopolysaccharide binding protein levels, identifying it as a novel biomarker of plaque rupture.
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