Key result
AFib is independently linked to greater severity and worse clinical outcomes in ischemic stroke patients.
Why the study?
The association of atrial fibrillation with ischemic stroke has emerged as a clinical research area, prompting investigation into possible correlations between AF and the severity, progress, and outcome of ischemic stroke.
Does the presence of atrial fibrillation worsen the severity, progress, and clinical outcome in patients with ischemic stroke?
Observational (n=344)
Does the presence of atrial fibrillation worsen the severity, progress, and clinical outcome in patients with ischemic stroke?
Atrial fibrillation is associated with increased severity, worse in-hospital progression, and poorer final clinical outcomes in patients with ischemic stroke.
AF may flag higher-risk ischemic stroke; extends associations but leaves causal impact and interventions open.
Background and Aim: The association of atrial fibrillation (AF) with the ischemic stroke has emerged as an area of clinical research. The purpose of the present study is to investigate possible correlations between the severity, progress, and outcome of ischemic stroke and the presence of AF. Materials and Methods and Results: The clinical assessment of patients was based on the neurological status at the time of diagnosis utilizing the National Institutes of Health Stroke Scale (NIHSS), the neurological semiology during hospitalization (improvement, deterioration, and without differentiation), and the final outcome at the end of the treatment optimizing the modified Rankin scale (mRS). A total of 344 patients diagnosed with an ischemic stroke were enrolled in the study. The presence of AF was found to be associated with higher severity, poorer progress, and more adverse clinical outcomes of the ischemic stroke. Furthermore, a lower frequency of transient ischemic attacks was observed in patients with AF. Finally, patients with AF presented higher incidence of middle cerebral artery occlusion and were more frequently found with a lesion on the left brain hemisphere. Conclusion: AF was found to be highly associated with higher severity and poorer prognosis of ischemic strokes, independently from the presence of other cardiovascular risk factors.
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Mavromoustakou et al. (2022) conducted an observational in Ischemic stroke (n=344). Atrial fibrillation (exposure) vs. No atrial fibrillation was evaluated on Severity (NIHSS), progress, and final outcome (mRS). Atrial fibrillation in ischemic stroke patients (N=344) was associated with higher severity, poorer progress, and more adverse clinical outcomes independently of other cardiovascular risk factors.
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