Genome- and Phenome-Wide Analyses of Cardiac Conduction Identifies Markers of Arrhythmia Risk
Key result
Sodium channel variants (SCN5A and SCN10A) modulating QRS duration in subjects without cardiac disease predicted subsequent atrial fibrillation and arrhythmias (SCN5A P=1.2x10^-8; SCN10A P=6x10^-6).
Why the study?
Are genetic variants associated with QRS duration predictors of subsequent arrhythmias in individuals without cardiac disease?
Population
5,272 individuals without cardiac disease from 5 sites in the eMERGE network, and 13,859 European Americans
Design
Cohort
Authors
Discussion
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Member takes
Implication
Supports arrhythmia risk stratification via SCN5A/SCN10A variants in healthy subjects; hypothesis-generating, needs prospective validation before practice change.
Study Design
Type
Observational (n=5,272)
Multicenter
Yes
Structured PICO
Are genetic variants associated with QRS duration predictors of subsequent arrhythmias in individuals without cardiac disease?
P
Population
5,272 individuals without cardiac disease from 5 sites in the eMERGE network (for GWAS), and 13,859 European Americans (for PheWAS)
I
Intervention
Genetic variants associated with QRS duration (specifically SCN5A and SCN10A loci)
O
Outcome
QRS duration (GWAS) and diagnoses of atrial fibrillation and cardiac arrhythmias (PheWAS)
Main Result
p-value: p=1.2x10(-8)
DNA biobanks coupled to electronic medical records identified sodium channel variants modulating QRS duration as predictors of subsequent arrhythmias in heart-healthy subjects.
Cite This Study
Ritchie et al. (2013) conducted an observational in Cardiac conduction and arrhythmia risk (n=5,272). SCN5A and SCN10A genetic variants was evaluated on Genomic markers of QRS duration (p=1.2x10(-8)). Sodium channel variants (SCN5A and SCN10A) modulating QRS duration in subjects without cardiac disease predicted subsequent atrial fibrillation and arrhythmias (SCN5A P=1.2x10^-8; SCN10A P=6x10^-6).