July 20, 2012Circulation ResearchOpen Access

Whither Art Thou, SCN10A, and What Art Thou Doing?

Q: What is the clinical evidence from this study?

Study design: Editorial. Population: Cardiac sodium channel diseases (e.g., LQT3, Brugada syndrome, sudden cardiac death). Intervention: SCN5A and SCN10A.

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Key result

SCN5A mutations and changes in its expression or function are implicated in various cardiac diseases leading to sudden cardiac death, including long-QT syndrome type 3 and Brugada syndrome.

Design

Editorial

Authors

BLBarry LondonElectrophysiology

Discussion

Member takes

Implication

Discusses the role of SCN5A and potentially SCN10A in cardiac sodium channel function and related arrhythmogenic diseases.

PICO

Population

Cardiac sodium channel diseases (e.g., LQT3, Brugada syndrome, sudden cardiac death)

Exposure / Comparator

SCN5A and SCN10A

Discusses the role of SCN5A and potentially SCN10A in cardiac sodium channel function and related arrhythmogenic diseases.

Cite This Study

Barry London (2012) conducted an editorial in Cardiac sodium channel diseases (e.g., LQT3, Brugada syndrome, sudden cardiac death). SCN5A and SCN10A was evaluated. SCN5A mutations and changes in its expression or function are implicated in various cardiac diseases leading to sudden cardiac death, including long-QT syndrome type 3 and Brugada syndrome.

synapsesocial.com/papers/6a7da2bf8b7e38892f1503bb https://doi.org/10.1161/circresaha.112.275032

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Whither Art Thou, SCN10A, and What Art Thou Doing?

Discussion

Member takes

Implication

PICO

Cite This Study

Whither Art Thou, SCN10A, and What Art Thou Doing?

Discussion

Member takes

Implication

PICO

Cite This Study

Also Consider

Also Consider