Key result
Experimental induction of atrial flutter in canine models demonstrated a reentrant impulse circulating around the tricuspid valve orifice, with tachycardia cycle lengths of 205 to 399 msec.
Population
Canine model of experimental atrial flutter
Design
Preclinical
Authors
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Supports tricuspid reentry in canine flutter models; leaves open translation to human mechanisms and therapy.
The study demonstrates that experimental atrial flutter in a canine model is driven by a reentrant circuit around the tricuspid valve orifice, supported by continuous propagation through the supravalvular lamina.
Frame et al. (1987) studied Atrial flutter (n=3). Electrophysiological mapping and pharmacological testing was evaluated on Activation sequence and mechanism of reentry. Experimental induction of atrial flutter in canine models demonstrated a reentrant impulse circulating around the tricuspid valve orifice, with tachycardia cycle lengths of 205 to 399 msec.
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