Key result
NMR structure determination reveals that the Ca2+ sensitizer EMD 57033 binds stereospecifically to the hydrophobic cleft of the C-domain of human cardiac troponin C.
The structural elucidation of the cCTnC-EMD 57033 complex provides mechanistic insights into how Ca2+ sensitizers interact with cardiac troponin, which has implications for heart failure drug development.
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Informs Ca2+ sensitizer design; leaves open clinical translation from this animal structural model.
Wang et al. (2001) studied Heart failure. EMD 57033 was evaluated on NMR structure of the 1:1 complex between Ca(2+)-saturated C-domain of human cTnC and EMD 57033. NMR structure determination reveals that the Ca2+ sensitizer EMD 57033 binds stereospecifically to the hydrophobic cleft of the C-domain of human cardiac troponin C.
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