Key result
Nonideal conditions caused activation time differences >1.8 msec and recovery time differences >30 msec between electrogram and action potential measurements, independent of action potential waveforms.
Population
A model of one-dimensional action potential propagation (simulation study)
Comparison
Measurement of activation and recovery times… vs Measurement of activation and recovery times…
Design
Preclinical
Authors
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Nonideal conditions may distort electrogram timings; animal data leave open clinical translation and require validation.
Simulation results demonstrate that activation and recovery times measured from extracellular electrograms can be significantly distorted by nonideal conditions independent of the underlying action potential waveforms.
B.M. Steinhaus (1989) studied Cardiac electrophysiology (simulation). Unipolar and bipolar extracellular electrograms vs. Simulated transmembrane action potentials was evaluated on Difference between electrogram and action potential activation and recovery times. Nonideal conditions caused activation time differences >1.8 msec and recovery time differences >30 msec between electrogram and action potential measurements, independent of action potential waveforms.
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