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June 1, 1986Annual Review of Biophysics and Biophysical Chemistry1,506 citationsOpen Access

Identifying Nonpolar Transbilayer Helices in Amino Acid Sequences of Membrane Proteins

DEDonald M. EngelmanTST.A. SteitzAGAdrian Goldman

Key Points

  • The aim is to identify nonpolar transbilayer helices within the amino acid sequences of membrane proteins.
  • Analyzed amino acid sequences of various membrane proteins to locate transbilayer helices.
  • Utilized computational algorithms to predict nonpolar regions in these sequences.
  • Identified several novel nonpolar transbilayer helices with high confidence.
  • Provided insights into structural patterns in membrane protein sequences.

Abstract

Many bacterial clustered regularly interspaced short palindromic repeats (CRISPR)–CRISPR-associated (Cas) systems employ the dual RNA–guided DNA endonuclease Cas9 to defend against invading phages and conjugative plasmids by introducing site-specific ...Read More

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Cite This Study

Engelman et al. (1986) studied this question.

synapsesocial.com/papers/6a0f7d25d13714ec96fe3868https://doi.org/10.1146/annurev.bb.15.060186.001541
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