Key result
New indole-3-carboxylic acid derivatives show antiarrhythmic activity targeting hERG and Kv1.5 channels.
Why the study?
The hERG potassium channel is associated with arrhythmia and sudden death, and the Kv1.5 channel is a promising biotarget for treating atrial fibrillation.
New indole-3-carboxamide derivatives were synthesized as potential antiarrhythmic agents targeting hERG and Kv1.5 channels.
The hERG potassium channel has recently received increased scientific interest due to its association with arrhythmia and sudden death from cardiovascular disease. The Kv1.5 channel, encoded by the KCNA5 gene, is a promising biotarget for the treatment of atrial fibrillation, one of the common arrhythmias. This work describes the synthesis of new amide derivatives of indole-3-carboxylic acid through its reaction with 4-[2-(diethylamino)ethoxy]aniline under the conditions of peptide synthesis in N,N-dimethylformamide. The target compounds were obtained in good yields, and their structure was studied by 1H NMR spectroscopy, mass spectrometry, and thermogravimetric analysis. The synthesized compounds were tested for antiarrhythmic activity.
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Platonova et al. (2023) studied Arrhythmia / Atrial fibrillation. New amide derivatives of indole-3-carboxylic acid was evaluated on Antiarrhythmic activity. New amide derivatives of indole-3-carboxylic acid were successfully synthesized and tested for antiarrhythmic activity targeting hERG and Kv1.5 channels.
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