Key result
PVCs linked to ~90% higher risk of atrial fibrillation.
Why the study?
Atrial fibrillation is more likely found in patients with premature ventricular complexes, but outcomes of previous investigations remain inconclusive.
Does the presence of premature ventricular complexes increase the risk of atrial fibrillation?
Meta-Analysis (n=9,662,088)
Does the presence of premature ventricular complexes increase the risk of atrial fibrillation?
Premature ventricular complexes are associated with a nearly twofold increased risk of developing atrial fibrillation.
INTRODUCTION: Atrial fibrillation (AF) is more likely found in patients with premature ventricular complexes (PVCs). Nonetheless, the outcomes of previous investigations remain inconclusive. To evaluate the link between PVCs and the risk of AF, we did a systematic review and meta-analysis.EVIDENCE ACQUISITION: Potentially eligible studies were found by searching for published publications indexed in the MEDLINE and EMBASE databases from inception to April 13, 2021, looking for studies that assessed the risk of AF in patients with PVCs vs. those who did not have PVCs. Dersimonian and Laird’s random-effect, generic inverse variance technique was used to calculate the pooled risk ratio (RR) and 95% confidence interval (CI).EVIDENCE SYNTHESIS: The meta-analysis includes 6 cohort studies (1 prospective and 5 retrospective cohort studies) with a total of 9,662,088 individuals. We found that patients with PVCs have a significantly higher risk of AF than individuals without PVCs with the pooled RR of 1.90 (95% CI: 1.51-2.39, I2=83%).CONCLUSIONS: PVCs are significantly related with a 1.90-fold higher incidence of AF, according to the present systematic review and meta-analysis. Nonetheless, further research is needed to determine how this connection should be treated in clinical practice if it is causal.
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Rujirachun et al. (2022) conducted a meta-analysis in Premature ventricular complexes (PVCs) (n=9,662,088). Premature ventricular complexes vs. No premature ventricular complexes was evaluated on Risk of atrial fibrillation (RR 1.90, 95% CI 1.51-2.39). Premature ventricular complexes were associated with a significantly higher risk of atrial fibrillation compared to individuals without PVCs (RR 1.90; 95% CI 1.51-2.39).
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