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June 27, 2026EP EuropaceOpen Access

PVCs were detected in 72.8% of AF patients and were significantly associated with older age (p=0.002), higher NT-proBNP (1120 vs 259 pg/mL, p<0.001), and predominantly originated from the left ventricle (69.3%).

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Why the study?

The pathophysiological relationship between PVCs and AF remains unclear, specifically whether PVCs arise secondary to AF remodeling or act as an independent arrhythmogenic trigger.

Population

103 consecutive AF patients without ischemic or structural heart disease

Comparison

Patients with PVCs vs patients without PVCs

Design

Observational cross-sectional study

Authors

OKO K KeskinASA T SahinAIA Icli

Discussion

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Overview

PVCs common in this cohort but should not change practice; leaves open their prognostic role.

Key Points

  • This study aims to evaluate the characteristics and anatomical origins of PVCs in atrial fibrillation patients without structural heart disease.
  • Included 103 patients with atrial fibrillation undergoing 24-hour ambulatory ECG monitoring.
  • Exclusion criteria comprised ischemic heart disease, structural heart disease, and Ashman aberrancy.
  • Compared demographic, comorbidity, laboratory, and echocardiographic parameters between patients with and without PVCs.
  • PVCs were found in 75 patients (72.8%); those with PVCs were older and had higher chronic kidney disease and diabetes rates.
  • Higher NT-proBNP positivity (72.0% vs. 35.7%; p<0.001) and mean NT-proBNP values were recorded in the PVC group (1120 pg/mL vs. 259 pg/mL; p<0.001).
  • PVCs mostly originated from the left ventricle (69.3%), with multifocal PVCs seen in 44% of cases.

Structured PICO

P
Population
103 consecutive patients diagnosed with atrial fibrillation (AF) who underwent 24-hour, 12-lead ambulatory electrocardiographic monitoring. Excluded: ischemic heart disease, structural heart disease, or Ashman aberrancy.
C
Comparator
Patients without premature ventricular complexes (PVCs)
O
Outcome
Frequency, burden, morphological characteristics, and anatomical origin of PVCs, and their association with clinical variables, laboratory markers, and echocardiographic parameterssurrogate

In patients with AF without structural heart disease, PVCs are highly prevalent, predominantly originate from the left ventricle, and are associated with advanced age, comorbidities, and elevated NT-proBNP.

Cite This Study

Keskin et al. (2026) studied this question.

synapsesocial.com/papers/6a3f97a5125782b61d865855https://doi.org/10.1093/europace/euag105.1166
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