Key result
Frequent premature ventricular contractions were associated with significantly lower global peak atrial longitudinal strain (30.85% vs 57.49%) and impaired left ventricular function compared to controls.
Why the study?
Premature ventricular contractions were previously considered benign, and their clinical significance in patients without structural heart disease remains controversial.
Do frequent PVCs adversely affect functional and structural echocardiography parameters in patients without structural heart disease?
Cross-Sectional (n=52)
Yes
Do frequent PVCs adversely affect functional and structural echocardiography parameters in patients without structural heart disease?
Mean Difference: -26.6 (95% CI -32.9–-20.3)
Absolute Event Rate: 30.85% vs 57.49%
p-value: p=<0.001
Frequent PVCs in patients without structural heart disease are associated with adverse subclinical changes in left atrial and left ventricular function and geometry as detected by strain echocardiography.
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Palpitations in frequent-PVC patients require symptom-rhythm correlation before attribution; leaves open whether PVCs cause symptoms in most without SHD.
Alimi et al. (2022) conducted a cross-sectional in Frequent premature ventricular contractions without structural heart disease (n=52). Frequent premature ventricular contractions (>10/hour) vs. No premature ventricular contractions was evaluated on Global peak atrial longitudinal strain (PALS) (MD -26.6, 95% CI -32.9, -20.3, p=<0.001). Frequent premature ventricular contractions were associated with significantly lower global peak atrial longitudinal strain (30.85% vs 57.49%) and impaired left ventricular function compared to controls.
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