What does this research mean for the field?

In asymptomatic patients with normal baseline left ventricular function, frequent premature ventricular contractions from the ventricular outflow tract have a generally benign prognosis for serious cardiac events, but a high PVC burden independently predicts the long-term development of left ventricular dysfunction. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research investigates the impact of frequent PVCs on long-term outcomes in patients with normal left ventricular function.

May 7, 2009HeartOpen Access

Prognostic significance of frequent premature ventricular contractions originating from the ventricular outflow tract in patients with normal left ventricular function

View Full Paper

Ask AI

Bookmark

Why the study?

Does the prevalence of frequent premature ventricular contractions predict the development of left ventricular dysfunction in asymptomatic patients with normal baseline LV function?

Population

239 consecutive asymptomatic patients with frequent premature ventricular contractions originating from the…

Design

Cohort

Follow-up

5.6 (1.7) years

Authors

SNS NiwanoKitasato University YWYoshinari WakisakaDaiyukai General Hospital HNHiroe NiwanoTamagawa University

Discussion

Member takes

Implication

May support closer LVEF surveillance in high-PVC patients; leaves open whether suppression prevents dysfunction.

Key Points

This research investigates the impact of frequent PVCs on long-term outcomes in patients with normal left ventricular function.
Enroll 239 patients with frequent PVCs originating from the ventricular outflow tract
Utilize echocardiography and cardiac MRI to rule out structural heart disease
Monitor patients for at least 4 years, evaluating PVC prevalence and LV function changes
During an average follow-up of 5.6 years, no serious cardiac events occurred
13 patients developed LV dysfunction with DeltaLVEF > -6%
PVC prevalence and initial LVEF were identified as independent predictors of LV dysfunction (p<0.01)

Structured PICO

Does the prevalence of frequent premature ventricular contractions predict the development of left ventricular dysfunction in asymptomatic patients with normal baseline LV function?

Population

239 consecutive asymptomatic patients with frequent premature ventricular contractions (>1000 beats/day) originating from the right or left ventricular outflow tract and normal left ventricular function without detectable structural heart disease.

Outcome

Serious cardiac events and development of left ventricular dysfunction (defined as DeltaLVEF > -6%)surrogate

Frequent PVCs from the ventricular outflow tract in patients with normal LV function have a benign prognosis regarding serious cardiac events, but high PVC prevalence independently predicts the progression of LV dysfunction over long-term follow-up.

Cite This Study

Niwano et al. (2009) studied this question.

synapsesocial.com/papers/6a1b7d486bdb5bd52d1cea0a https://doi.org/10.1136/hrt.2008.159558

View Full Paper

Ask AI

Bookmark

Prognostic significance of frequent premature ventricular contractions originating from the ventricular outflow tract in patients with normal left ventricular function

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Prognostic significance of frequent premature ventricular contractions originating from the ventricular outflow tract in patients with normal left ventricular function

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider