Key result
Frequent premature ventricular complexes (>10/h) were associated with a significantly larger left atrial volume index compared to matched controls (28 vs. 24 mL/m2; P<0.05).
Why the study?
Are frequent premature ventricular complexes associated with early cardiac structural and functional changes in patients with normal left ventricular ejection fraction?
Case-Control (n=438)
Are frequent premature ventricular complexes associated with early cardiac structural and functional changes in patients with normal left ventricular ejection fraction?
Absolute Event Rate: 28% vs 24%
p-value: p=<0.05
Frequent premature ventricular complexes are associated with left atrial enlargement and early structural remodeling even before the onset of overt left ventricular systolic dysfunction.
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May signal early atrial remodeling in preserved EF; hypothesis-generating for prospective PVC suppression trials.
Park et al. (2014) conducted a case-control in Frequent premature ventricular complex with normal left ventricular ejection fraction (n=438). Frequent premature ventricular complex vs. Age- and sex-matched control group was evaluated on Left atrial volume index (LAVI) (p=<0.05). Frequent premature ventricular complexes (>10/h) were associated with a significantly larger left atrial volume index compared to matched controls (28 vs. 24 mL/m2; P<0.05).
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