Key result
Long-term oxygen therapy (15-18 h/day) reversed pulmonary hypertension progression in severe COPD, changing the yearly pulmonary arterial pressure from a 1.47 mmHg increase to a 2.15 mmHg decrease.
Why the study?
Does long-term oxygen therapy reverse the progression of pulmonary hypertension in patients with severe COPD?
Population
16 patients with severe chronic obstructive pulmonary disease (COPD)
Comparison
Long-term oxygen therapy for 31 +/- 19 months vs Patients' own prior trajectory before the onset…
Design
Cohort
Follow-up
31 +/- 19 months
Authors
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Supports LTOT consideration for PH in severe COPD; leaves open causality and optimal use pending RCTs.
Cohort (n=16)
Does long-term oxygen therapy reverse the progression of pulmonary hypertension in patients with severe COPD?
Absolute Event Rate: -2.15% vs 1.47%
p-value: p=<0.05
Long-term oxygen therapy for 15 to 18 hours per day can reverse the progression of pulmonary hypertension in patients with severe COPD, although normalization of pulmonary arterial pressure is rare.
Weitzenblum et al. (1985) conducted a cohort in severe chronic obstructive pulmonary disease (COPD) (n=16). Long-term oxygen therapy vs. Pre-treatment period was evaluated on Yearly change in mean pulmonary arterial pressure (Ppa) in mmHg (p=<0.05). Long-term oxygen therapy (15-18 h/day) reversed pulmonary hypertension progression in severe COPD, changing the yearly pulmonary arterial pressure from a 1.47 mmHg increase to a 2.15 mmHg decrease.
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