Shows a significant relationship among angiotensinogen, alpha 1-antitrypsin, antithrombin III, and ovalbumin, highlighting their common ancestry.
The recently reported amino acid sequence of rat angiotensinogen was subjected to a computer-assisted search for homology with known sequences stored in a data bank and found to be significantly related to that of plasma alpha 1-antitrypsin, itself a member of a family that includes antithrombin III and ovalbumin. An alignment of the four sequences shows indisputably the common ancestry of all four proteins.
No takes yet. Share an insight, caveat, or question.
Russell F. Doolittle (1983) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: