Key result
New antiarrhythmic drugs introduced over the past decade overwhelmingly fit into the four originally described classes of action, with alinidine potentially representing a fifth class.
Design
Review
Authors
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The four-class system remains applicable to recent antiarrhythmics; leaves open whether a fifth class will emerge.
The original four-class system for antiarrhythmic actions remains robust and applicable to new drugs introduced over the subsequent decade.
E. M. Vaughan Williams (1984) conducted a review in Arrhythmias. Antiarrhythmic drugs was evaluated. New antiarrhythmic drugs introduced over the past decade overwhelmingly fit into the four originally described classes of action, with alinidine potentially representing a fifth class.
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