Key result
Enteroviral RNA positivity in myocardial tissue was strongly associated with acute myocarditis (OR 4.4) and dilated cardiomyopathy (OR 3.8).
Why the study?
Is the presence of enteroviruses associated with acute myocarditis and dilated cardiomyopathy?
Population
Patients with acute myocarditis (12 studies) or dilated cardiomyopathy (17 studies)
Comparison
Detection of enteroviruses using molecular… vs Control populations without these conditions
Design
Meta-analysis
Authors
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Supports enteroviral testing in suspected myocarditis; confirms tissue RNA associations with acute disease and dilated cardiomyopathy.
Meta-Analysis
Is the presence of enteroviruses associated with acute myocarditis and dilated cardiomyopathy?
Effect estimate: OR 4.4 (acute myocarditis), OR 3.8 (DCM)
This meta-analysis supports a causative role for enteroviruses in acute myocarditis and suggests an association with dilated cardiomyopathy.
Baboonian et al. (1997) conducted a meta-analysis in Dilated cardiomyopathy (DCM) and acute myocarditis. Enterovirus infection vs. Non-diseased population was evaluated on Enteroviral RNA positivity in myocardial tissue (OR 4.4 (acute myocarditis), OR 3.8 (DCM)). Enteroviral RNA positivity in myocardial tissue was strongly associated with acute myocarditis (OR 4.4) and dilated cardiomyopathy (OR 3.8).
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