Why the study?
Is enteroviral RNA detectable in endomyocardial biopsy tissues of patients with myocarditis and dilated cardiomyopathy?
Population
46 patients, comprising 36 with myocarditis and 10 with non-infectious cardiac diseases (controls).
Comparison
Nested reverse transcriptase polymerase chain… vs Patients with non-infectious cardiac diseases
Design
Case-control
Follow-up
3 weeks to 8 years for repeat biopsies
Authors
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Enteroviral persistence may occur in myocarditis; hypothesis-generating for progression to dilated cardiomyopathy and requires prospective validation.
Is enteroviral RNA detectable in endomyocardial biopsy tissues of patients with myocarditis and dilated cardiomyopathy?
Enteroviral infection is a probable cause of myocarditis and viral RNA may persist in the myocardium during progression to dilated cardiomyopathy.
Satoh et al. (1994) studied this question.
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