Key result
Enteroviral RNA is detected in ~49% of DCM patients and linked to rapid heart failure progression.
Why the study?
The exact cause of dilated cardiomyopathy remains uncertain, with a suspected transition from coxsackievirus-infected myocarditis to DCM.
Case-Control (n=45)
Absolute Event Rate: 49% vs 0%
Enteroviral infection may play a significant role in the pathogenesis of dilated cardiomyopathy and is associated with rapid progression to heart failure and marked histological changes.
Enteroviral detection may implicate infection in DCM progression; leaves open whether screening or antivirals alter outcomes.
The exact cause of dilated cardiomyopathy (DCM) remains uncertain. However, a possibility of transition from coxsackievirus-infected myocarditis to DCM has been suspected. We investigated the role of enteroviral infection in the pathogenesis of DCM. The nested reverse transcriptase polymerase chain reaction (nRT-PCR) was used to detect enteroviral RNA in 45 endomyocardial biopsy tissues obtained from 35 patients with DCM and 10 patients (controls) with other non-infectious cardiac diseases. Enteroviral RNA was detected in 17 (49%) of the 35 patients with DCM. The progression to cardiac failure was rapid, usually within 12 months, and myocardial fibrosis and myocytic hypertrophy were marked in patients that were enteroviral RNA positive. Enteroviral RNA was not detected in any controls.
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Satoh et al. (1994) conducted a case-control in Dilated cardiomyopathy (n=45). Dilated cardiomyopathy vs. Other non-infectious cardiac diseases was evaluated on Detection of enteroviral RNA. Enteroviral RNA was detected in 49% of patients with dilated cardiomyopathy compared to 0% of controls, and was associated with rapid progression to cardiac failure.
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