Key result
Enteroviral RNA was detected in 72% of explanted myocardium specimens from patients with dilated or ischemic cardiomyopathy, compared to 0% in control specimens.
Why the study?
Is enteroviral RNA more frequently detected in the explanted myocardium of patients with end-stage dilated or ischemic cardiomyopathy compared to controls?
Case-Control (n=69)
Is enteroviral RNA more frequently detected in the explanted myocardium of patients with end-stage dilated or ischemic cardiomyopathy compared to controls?
Enteroviral RNA is highly prevalent in the explanted hearts of patients with end-stage dilated and ischemic cardiomyopathy compared to controls, suggesting a potential pathogenic role for enteroviruses in these conditions.
Answers are grounded in this paper and cite their sources.
Should not yet change cardiomyopathy management; leaves open a possible enteroviral role for prospective study.
Enteroviral RNA (EV-RNA) was detected in endomyocardial tissue by means of retrotranscription and polymerase chain reaction (RT-PCR) followed by slot-blot hybridization. The myocardial biopsy specimens studied were taken at the time of heart transplantation from 15 patients with dilated cardiomyopathy (DCM) and from 10 patients with ischemic cardiomyopathy (ICM). Specimens from 18 (72%) of the 25 patients were positive for EV-RNA, whereas no control specimens (myocardial specimens from 29 healthy organ donors and atrial specimens from 15 patients with acute myocardial infarction treated by anatomic bypass) yielded evidence of EV-RNA. The rates of EV-RNA detection for the two groups requiring heart transplantation did not differ significantly (66.7% vs. 80.0%; chi 2 test). Our findings support a link between enteroviral infection in both DCM and ICM and suggest a pathogenic role for the enteroviruses.
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Andréoletti et al. (1995) conducted a case-control in Dilated or Ischemic Cardiomyopathy (n=69). Enteroviral infection vs. Healthy organ donors and patients with acute myocardial infarction was evaluated on Detection of Enteroviral RNA (EV-RNA) in myocardial biopsy specimens. Enteroviral RNA was detected in 72% of explanted myocardium specimens from patients with dilated or ischemic cardiomyopathy, compared to 0% in control specimens.
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