Key result
Enteroviral RNA was detected in only 3.1% of myocardial specimens from children with end-stage idiopathic dilated cardiomyopathy and 0% of control specimens, indicating no significant role.
Why the study?
Does enteroviral persistence play a significant role in the pathogenesis of end-stage idiopathic dilated cardiomyopathy in children and adolescents?
Population
33 children and adolescents with end-stage idiopathic dilated cardiomyopathy (IDCM)
Comparison
Polymerase chain reaction and in situ… vs 34 control specimens from children with other…
Design
Case-control
Authors
Loading...
Questions enteroviral role in pediatric end-stage DCM; leaves open alternative mechanisms for prospective study.
Observational (n=67)
Does enteroviral persistence play a significant role in the pathogenesis of end-stage idiopathic dilated cardiomyopathy in children and adolescents?
Absolute Event Rate: 3.1% vs 0%
Enteroviral persistence does not appear to be a significant factor in the progression of idiopathic dilated cardiomyopathy to end-stage heart failure in children and adolescents.
Arola et al. (1998) conducted an observational in End-stage idiopathic dilated cardiomyopathy (n=67). Polymerase chain reaction (PCR) and in situ hybridization vs. Specimens from children with other cardiomyopathies, metabolic diseases, structural heart defects, or noncardiac malignancies was evaluated on Detection of enteroviral RNA. Enteroviral RNA was detected in only 3.1% of myocardial specimens from children with end-stage idiopathic dilated cardiomyopathy and 0% of control specimens, indicating no significant role.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: