Key result
Enterovirus genome was detected in 35.7% of patients with idiopathic dilated cardiomyopathy and 32.8% of patients with chronic coronary disease (P=.12), with none detected in healthy controls.
Why the study?
Does enterovirus persist or actively replicate in the cardiac tissue of patients with end-stage ischemic or dilated cardiomyopathy?
Population
179 subjects, including 70 patients with idiopathic dilated cardiomyopathy, 64 patients with chronic…
Comparison
Examination of endomyocardial biopsies from… vs Donors of healthy hearts (controls).
Design
Cross-sectional
Authors
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Enterovirus genome in myocardium of chronic cardiomyopathy may reflect latent infection; leaves open its pathogenic role and need for targeted antivirals.
Observational (n=179)
Does enterovirus persist or actively replicate in the cardiac tissue of patients with end-stage ischemic or dilated cardiomyopathy?
Absolute Event Rate: 35.7% vs 32.8%
p-value: p=.12
A small percentage of patients with end-stage chronic cardiac diseases have active enterovirus replication in their myocardium, while the majority of infected patients exhibit latent infection.
Andréoletti et al. (2000) conducted an observational in End-stage ischemic or dilated cardiomyopathy (n=179). Idiopathic dilated cardiomyopathy vs. Chronic coronary disease was evaluated on Detection of enterovirus genome (p=.12). Enterovirus genome was detected in 35.7% of patients with idiopathic dilated cardiomyopathy and 32.8% of patients with chronic coronary disease (P=.12), with none detected in healthy controls.
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