What question did this study set out to answer?

To develop a noninvasive assay to detect gluten intake and evaluate whether urinary gluten immunogenic peptides correlate with intestinal mucosal damage in coeliac disease.

November 25, 2015GutOpen Access

Detection of gluten immunogenic peptides in the urine of patients with coeliac disease reveals transgressions in the gluten-free diet and incomplete mucosal healing

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Authors

MMMaría de Lourdes MorenoUniversidad de Sevilla ÁCÁngel CebollaBiomedal (Spain)AMAlba Muñoz-SuanoBiomedal (Spain)

Discussion

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Implication

Randomized trial reveals urinary gluten immunogenic peptides detect diet lapses and gut damage in celiac disease, indicating a reliable noninvasive monitoring tool.

Key Points

To develop a noninvasive assay to detect gluten intake and evaluate whether urinary gluten immunogenic peptides correlate with intestinal mucosal damage in coeliac disease.
Clinical trial (NCT02344758) evaluating urine samples from 76 healthy controls and 58 patients with coeliac disease under distinct dietary gluten conditions.
Solid-phase extracted urine was tested using a lateral flow test incorporating the G12 monoclonal antibody to quantify dominant gluten immunogenic peptides.
Urinary peptide excretion was compared against duodenal biopsy findings assessing villous atrophy and mucosal recovery.
Gluten immunogenic peptides appeared in concentrated urine 4–6 hours after a single gluten intake and remained detectable for 1–2 days.
The urinary assay detected gluten-free diet transgressions in approximately 50% of participating patients with coeliac disease.
Among patients without villous atrophy, 89% had no detectable peptides in urine, whereas 100% of patients with quantifiable urinary peptides exhibited incomplete mucosal recovery.

Cite This Study

Moreno et al. (2015) studied this question.

synapsesocial.com/papers/6a0f932d4fb650da4ffe43e8 https://doi.org/10.1136/gutjnl-2015-310148

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Implication

Randomized trial reveals urinary gluten immunogenic peptides detect diet lapses and gut damage in celiac disease, indicating a reliable noninvasive monitoring tool.

Detection of gluten immunogenic peptides in the urine of patients with coeliac disease reveals transgressions in the gluten-free diet and incomplete mucosal healing

Discussion

Member takes

Implication

Key Points

Cite This Study

Detection of gluten immunogenic peptides in the urine of patients with coeliac disease reveals transgressions in the gluten-free diet and incomplete mucosal healing

Discussion

Member takes

Implication

Key Points

Cite This Study

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