Key result
Warfarin discontinuation rates are not consistently higher than alternatives like aspirin, though non-adherence is linked to younger age, male sex, lower stroke risk, and poor cognitive function.
Why the study?
What are the determinants of adherence and persistence on long-term warfarin therapy for atrial fibrillation and venous thromboembolism?
Population
Patients on long-term anticoagulant therapy for atrial fibrillation and venous thromboembolism
Comparison
Warfarin vs Alternatives such as aspirin (in discussed trials)
Design
Review
Authors
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Supports monitoring younger males and cognitively impaired patients; leaves open prospective trials of adherence interventions.
What are the determinants of adherence and persistence on long-term warfarin therapy for atrial fibrillation and venous thromboembolism?
Warfarin has modest adverse effects on quality of life, and discontinuation rates are not consistently higher than alternatives, though several demographic and clinical risk factors for non-adherence exist.
Margaret C. Fang (2010) conducted a review in Atrial fibrillation and venous thromboembolism. Warfarin vs. Alternatives (such as aspirin) was evaluated on Adherence and persistence. Warfarin discontinuation rates are not consistently higher than alternatives like aspirin, though non-adherence is linked to younger age, male sex, lower stroke risk, and poor cognitive function.
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