Evaluation of biochemical parameters in acute myocardial infarction and angina patients

Background: Early and accurate detection of acute myocardial infarction (AMI) is an important unmet clinical requirement. The present study sought to evaluate the levels of N-terminal pro-brain natriuretic peptide (NTproBNP), cardiac troponin I (cTnI), fasting lipid profile, random blood sugar, and serum creatinine in AMI patients compared to angina patients. Methods: In a single-center, hospital-based, cross-sectional, observational, prospective study conducted at Gandhi Medical College, Secunderabad, from October-2018 to September-2019. A total of 150 patients aged above 40 years with acute chest pain (within 2-6 hours) and who were clinically susceptive of AMI and angina were investigated. The patients were divided into group I (50 AMI patients) and group II (100 angina patients). Levels of all biochemical parameters of blood were assessed. The statistical analyses were performed using the SPSS statistical software, version 15. A student t-test was used to compare the continuous variables between the two groups. Results: Out of 150 patients, higher male prevalence was found in both the groups (60% and 63%, respectively). Group I had higher levels of NTproBNP (2909±273pg/ml vs. 110±20.74pg/ml, P<0.01), cTnI (2.06±1.3ng/ml vs. 0.006±0.002ng/ml, P<0.01), and fasting lipid profile (total cholesterol:216±41.2mg/dl vs.201±32.5mg/dl, P<0.05, triglycerides:217.7±63.6 mg/dl vs. 175.3±48.8 mg/dl, P<0.01, low-density lipoprotein:141.7mg/dl±41.5 vs. 127.1±30.24 mg/dl, P<0.05, very low-density lipoprotein:43.4±12.8mg/dl vs. 35.1±9.8mg/dl, P<0.01) than group II, except low levels of high-density lipoprotein (31.2±3.83mg/dl vs. 38.9±4.32 mg/dl, P<0.01). Conclusion: Assessment of NTproBNP, cTnI, and fasting lipid profile may aid in the early diagnosis of AMI and its management.