Key result
A computer model of a cardiac fiber demonstrated that cellular uncoupling plays an important role in the genesis and maintenance of unidirectional block and reentry.
Computer simulations demonstrate that cellular uncoupling plays a critical role in the genesis and maintenance of unidirectional block and reentry arrhythmias.
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Suggests cellular uncoupling contributes to reentry; leaves open validation in intact hearts and patients.
Quan et al. (1990) studied Unidirectional block and reentry of cardiac excitation. Premature stimuli under different degrees of cell-to-cell coupling and membrane excitability was evaluated on Genesis of unidirectional block and reentry. A computer model of a cardiac fiber demonstrated that cellular uncoupling plays an important role in the genesis and maintenance of unidirectional block and reentry.
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