What question did this study set out to answer?

To assess the long-term incidence, clinical correlates, neurological severity, and mortality impact of stroke over two years of support with HeartMate 3 versus HeartMate II devices.

January 7, 2019CirculationOpen Access

Comprehensive Analysis of Stroke in the Long-Term Cohort of the MOMENTUM 3 Study

View Full Paper

Ask AI

Bookmark

Authors

PCP.C. ColomboHeart Failure & Transplant MMMandeep R. MehraHeart Failure & Transplant DGDaniel J. GoldsteinCardiac Surgery

Discussion

Member takes

Implication

Randomized trial demonstrates lower long-term stroke rates with centrifugal-flow pumps in advanced heart failure, highlighting significant survival advantages over axial-flow devices.

Key Points

To assess the long-term incidence, clinical correlates, neurological severity, and mortality impact of stroke over two years of support with HeartMate 3 versus HeartMate II devices.
Randomized controlled trial (NCT02224755) comparing the centrifugal-flow HeartMate 3 (N=189) to the axial-flow HeartMate II (N=172) in 361 patients with advanced heart failure.
Evaluated stroke subtypes (ischemic versus hemorrhagic), neurological disability via the modified Rankin Scale, and clinical correlates over two years of mechanical support.
Stroke rates did not differ within the first 180 days, but long-term stroke incidence (181-730 days) was significantly lower with HeartMate 3 than HeartMate II (0.04 vs 0.13 events per patient-year; OR 0.23, 95% CI 0.08-0.63, P=0.01).
Treatment with the HeartMate 3 pump was the only independent predictor of reduced stroke events, with no direct association identified for blood pressure or antithrombotic regimens.
Any stroke event significantly reduced 2-year postimplantation survival compared with no stroke (hemorrhagic: 43±12%, ischemic: 57±9%, disabling: 51±11%, nondisabling: 51±11% vs 85±2% without stroke).

Cite This Study

Colombo et al. (2019) studied this question.

synapsesocial.com/papers/6a0f9e1cd03631df9ce9cda3 https://doi.org/10.1161/circulationaha.118.037231

View Full Paper

Ask AI

Bookmark

Implication

Randomized trial demonstrates lower long-term stroke rates with centrifugal-flow pumps in advanced heart failure, highlighting significant survival advantages over axial-flow devices.

Comprehensive Analysis of Stroke in the Long-Term Cohort of the MOMENTUM 3 Study

Discussion

Member takes

Implication

Key Points

Cite This Study

Comprehensive Analysis of Stroke in the Long-Term Cohort of the MOMENTUM 3 Study

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider