Key result
Circulating miR-1185-1-3p, miR-550a-3p, and miR-885-5p are linked to adverse cardiac remodeling and higher BMI post-ACS.
Why the study?
Given elevated mortality in individuals with ACS and increased adiposity, delineating molecular mechanisms of obesity-associated adverse cardiac remodeling is critical for identifying novel biomarkers and therapeutic targets.
Are specific circulating extracellular RNAs associated with echocardiographic markers of adverse cardiac remodeling and elevated BMI in ACS survivors?
Cohort (n=296)
Are specific circulating extracellular RNAs associated with echocardiographic markers of adverse cardiac remodeling and elevated BMI in ACS survivors?
Specific circulating extracellular RNAs (miR-1185-1-3p, miR-550a-3p, and miR-885-5p) may serve as novel biomarkers for obesity-associated adverse cardiac remodeling in ACS survivors.
Hypothesis-generating for miR biomarkers in post-ACS remodeling; requires prospective validation before clinical use.
OBJECTIVE: Given the elevated mortality in individuals with acute coronary syndrome and increased adiposity, delineating the molecular mechanisms underlying obesity-associated adverse cardiac remodeling is critical for the identification of novel pathophysiological biomarkers and potential therapeutic targets. Circulating extracellular RNAs (ex-RNAs) regulate important biological processes and can serve as biomarkers of disease. This study aims to discover circulating extracellular RNAs (ex-RNAs) that serve as biomarkers of obesity-associated adverse cardiac remodeling in ACS survivors. METHODS: We analyzed extracellular RNA (ex-RNA) profiles in 296 survivors of acute coronary syndrome enrolled in the Transitions, Risks, and Actions in Coronary Events - Center for Outcomes Research and Education (TRACE-CORE) cohort. A total of 317 ex-RNAs were quantified, selected a priori based on prior findings from a large population-based study. We employed a two-step, mechanism-driven approach to identify ex-RNAs associated with echocardiographic phenotypes, including left atrial (LA) dimension, LA volume index, left ventricular (LV) ejection fraction, LV mass, and LV end-diastolic volume, then tested the relations of these ex-RNAs with obesity. We performed further bioinformatics analysis of the gene ontology categories and molecular pathways associated with predicted miRNA targets. RESULTS: We identified 45 ex-RNAs associated with at least one echocardiographic phenotype, of which miR-1185-1-3p, miR-550a-3p, and miR-885-5p were also associated with prevalent obesity. Bioinformatic analysis of their predicted gene targets (n=1,930) revealed enrichment in key pathways related to inflammation, fibrosis, and cellular toxicity, including Wnt/β-catenin signaling, TGF-β signaling, and hypoxia-inducible factor (HIF) signaling. Targets such as DICER1, VEGF, and EPO were implicated. Gene ontology analysis further highlighted associations with angiogenesis, FGF signaling, and interleukin pathways. CONCLUSIONS: Among ACS survivors, we observed that miR-1185-1-3p, miR-550a-3p, and miR-885-5p were associated with both echocardiographic markers of adverse cardiac remodeling and elevated BMI. Relevance for patients: miR-1185-1-3p, miR-550a-3p, and miR-885-5p were associated with echocardiographic phenotypes and obesity and are potential biomarkers for adverse cardiac remodeling in obesity.
No takes yet. Share an insight, caveat, or question.
Katherine Tak (2025) conducted a cohort in Acute coronary syndrome (n=296). Circulating extracellular RNAs (ex-RNAs) profiling was evaluated on Association of ex-RNAs with echocardiographic phenotypes and obesity. Circulating miR-1185-1-3p, miR-550a-3p, and miR-885-5p were associated with echocardiographic markers of adverse cardiac remodeling and elevated BMI in 296 acute coronary syndrome survivors.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: