Why the study?
Are circulating extracellular RNAs associated with left ventricular remodeling and incident heart failure in a community-based cohort?
Population
2763 participants of the Framingham Heart Study, mean age 66.3 years, 1499 female.
Design
Cohort
Follow-up
median 7.7 (IQR 6.6-8.6) years
Authors
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Should not yet guide HF risk assessment; leaves open miRNA biomarker utility pending prospective validation.
Are circulating extracellular RNAs associated with left ventricular remodeling and incident heart failure in a community-based cohort?
Specific circulating microRNAs (miR-17, miR-20a, and miR-106b) are associated with a reduced risk of incident heart failure and may serve as novel biomarkers for myocardial remodeling.
Shah et al. (2018) studied this question.
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