Assessing the Risk of Bleeding in Patients With Atrial Fibrillation
Key result
The HAS-BLED score significantly improved net reclassification for predicting bleeding events compared to other risk scores, though all scores had modest predictive ability (c-statistic ≈0.6).
Why the study?
Does the HAS-BLED score improve bleeding risk prediction compared to other bleeding risk scores in patients with nonvalvular atrial fibrillation?
Population
Patients diagnosed with nonvalvular atrial fibrillation in a 4-hospital institution between 2000 and 2010.
Comparison
HAS-BLED score for bleeding risk estimation vs Other older bleeding risk scores and the…
Design
Cohort
Authors
Discussion
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Member takes
Implication
Clinicians should interpret all AF bleeding scores cautiously; extends comparative data but leaves open outcome impact.
Study Design
Type
Cohort
Multicenter
Yes
Structured PICO
Does the HAS-BLED score improve bleeding risk prediction compared to other bleeding risk scores in patients with nonvalvular atrial fibrillation?
P
Population
Patients diagnosed with nonvalvular atrial fibrillation in a 4-hospital institution between 2000 and 2010.
I
Intervention
HAS-BLED score for bleeding risk estimation
C
Comparator
Other older bleeding risk scores and the Anticoagulation and Risk Factors in Atrial Fibrillation (ATRIA) score
O
Outcome
Bleeding events (assessed via c-statistic and net reclassification improvement)safety
The HAS-BLED score provides significantly improved reclassification for predicting bleeding events in patients with atrial fibrillation compared to older scores and the ATRIA score.
Cite This Study
Lip et al. (2012) conducted a cohort in Nonvalvular atrial fibrillation. HAS-BLED score vs. Older bleeding risk scores and the Anticoagulation and Risk Factors in Atrial Fibrillation score was evaluated on Bleeding events. The HAS-BLED score significantly improved net reclassification for predicting bleeding events compared to other risk scores, though all scores had modest predictive ability (c-statistic ≈0.6).