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January 1, 2005Thrombosis and Haemostasis

A patient with stent thrombosis, clopidogrel-resistance and failure to metabolize clopidogrel to its active metabolite

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Key result

A patient with stent thrombosis exhibited clopidogrel resistance due to a failure to metabolize clopidogrel into its active metabolite.

Population

1 patient with stent thrombosis and clopidogrel resistance

Design

Case_report

Authors

DTDirk TaubertUniversity Hospital CologneGPGisela Pogátsa-MurrayDeutsches Herzzentrum der CharitéAWAnna WieczorekEindhoven University of Technology

Discussion

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Implication

Alerts clinicians to test clopidogrel metabolism after stent thrombosis; hypothesis-generating and should not yet change practice.

Study Design

Type

Case Report (n=1)

Structured PICO

P
Population
1 patient with stent thrombosis and clopidogrel resistance
I
Intervention
Clopidogrel
O
Outcome
Stent thrombosis and failure to metabolize clopidogrel to its active metabolite

This case highlights the clinical risk of stent thrombosis in patients with clopidogrel resistance due to impaired drug metabolism.

Cite This Study

Taubert et al. (2005) conducted a case report in Stent thrombosis and clopidogrel resistance (n=1). Clopidogrel was evaluated. A patient with stent thrombosis exhibited clopidogrel resistance due to a failure to metabolize clopidogrel into its active metabolite.

synapsesocial.com/papers/6a0f9fc1e3460f6d4c1cd4e2https://doi.org/10.1055/s-0037-1616781
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Also Consider

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  1. 1Clopidogrel resistance and its relevance: Current concepts2024 · 13 citations
  2. 2Thienopyridines in cardiovascular disease: Focus on Clopidogrel resistance2007 · 98 citations
  3. 3Clopidogrel Resistance: Identifying and Overcoming a Barrier to Effective Antiplatelet Treatment2011 · 38 citations
  4. 4Antiplatelet Drug Resistance and Variability in Response: The Role of Antiplatelet Therapy Monitoring2013 · 19 citations
  5. 5Clopidogrel Resistance: Fact and Fiction2006 · 24 citations