Key result
Benzodiazepine administration significantly increased time spent in the lying position and subjective sleepiness (p < 0.01), with lorazepam increasing and alprazolam reducing mean heart rate.
Why the study?
Do benzodiazepines (lorazepam or alprazolam) alter physical activity, posture, sleepiness, and heart rate compared to placebo in healthy men?
Population
12 healthy men
Comparison
Oral dose of 2 mg lorazepam, 0.5 mg alprazolam… vs Placebo
Design
RCT, randomized, crossover, double-blind
Follow-up
4 hours per day on 4 different days
Authors
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Warrants caution with benzodiazepines due to increased recumbency and HR changes; extends accelerometry validation for quantifying acute drug effects.
RCT (n=12)
Double-blind
Crossover
Do benzodiazepines (lorazepam or alprazolam) alter physical activity, posture, sleepiness, and heart rate compared to placebo in healthy men?
p-value: p=<0.01
Ambulatory accelerometry is a reliable tool to quantify physical activity and posture, demonstrating that benzodiazepines significantly alter posture, motility, and heart rate in healthy men.
Tulen et al. (1997) conducted an RCT in Healthy (n=12). Lorazepam and alprazolam vs. Placebo was evaluated on Physical activities (body posture, motility), subjective sleepiness, and mean heart rate (p=<0.01). Benzodiazepine administration significantly increased time spent in the lying position and subjective sleepiness (p < 0.01), with lorazepam increasing and alprazolam reducing mean heart rate.
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