Key result
Saffold cardiovirus prevalence reaches 3.6% in pediatric HFMD, exceeding rates in respiratory infections and diarrhea.
Cohort (n=6,052)
No
p-value: p=<0.001
Saffold cardiovirus is present in pediatric patients in China, with a significantly higher prevalence and potential association with severe clinical outcomes in hand, foot, and mouth disease (HFMD).
May suggest Saffold cardiovirus role in pediatric HFMD; hypothesis-generating and requires prospective validation before any clinical consideration.
The epidemiology and clinical features of the Saffold cardiovirus (SAFV) remain ambiguous. The present study was designed to systematically and intensively investigate the epidemiological features of SAFV in pediatric patients in China. Three cohorts of pediatric patients were recruited from 2009 to 2012. Cohort 1 comprised patients with acute respiratory tract infections. Cohort 2 comprised patients with diarrhea. Cohort 3 comprised hand, foot, and mouth disease (HFMD) patients. A total of 115 patients (1.6%) among 6052 (17/1647, 12/2013, and 86/2392 in cohorts 1, 2, and 3, respectively) were SAFV-positive. The samples from 82 SAFV-positive patients were successfully sequenced, and four genotypes were identified: 8 SAFV-1, 41 SAFV-2, 29 SAFV-3, and 4 SAFV-6. A significantly higher detection rate was found in the HFMD patients than in other two cohorts (both P <0.001). A higher frequency of severe clinical outcome and nervous system manifestation were also observed in the SAFV-positive HFMD patients. Additionally, 6 (3.5%) cerebrospinal fluid and 7 (2.2%) serum samples from the HFMD-associated encephalitis patients were SAFV-positive. Based on the VP1 sequences, all four genotypes displayed distinct geographical clustering. SAFV infection might be associated with a wide clinical spectrum and contribute to HFMD.
No takes yet. Share an insight, caveat, or question.
Zhang et al. (2015) conducted a cohort in Acute respiratory tract infections, diarrhea, and hand, foot, and mouth disease (n=6,052). Saffold cardiovirus (SAFV) detection vs. Other pediatric cohorts (ARTI, diarrhea) was evaluated on Prevalence of SAFV in HFMD patients compared to ARTI and diarrhea patients (p=<0.001). Saffold cardiovirus was detected in 1.9% of pediatric patients overall, with a significantly higher prevalence of 3.6% in patients with hand, foot, and mouth disease compared to those with respiratory infections or diarrhea.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: