Adherence and Persistence with Methotrexate in Rheumatoid Arthritis: A Systematic Review
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Discussion
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Implication
Systematic review assesses methotrexate adherence and persistence in rheumatoid arthritis, indicating potential impacts on health outcomes.
Key Points
- The aim is to evaluate methotrexate adherence and persistence in patients with rheumatoid arthritis, along with factors influencing these outcomes.
- Systematic search of MEDLINE and Embase for studies on methotrexate adherence in rheumatoid arthritis from inception to February 2016.
- Inclusion of observational or interventional studies reporting adherence and persistence to methotrexate in rheumatoid arthritis.
- Data extraction using a standardized template for study design, demographics, and outcomes.
- 31 articles met inclusion criteria from 365 references screened, with 10 additional articles identified.
- MTX persistence rates ranged from 50% to 94% at 1 year and 25% to 79% at 5 years.
- No consistent trends in factors influencing MTX adherence were identified, but two studies indicated adherence related to superior clinical outcomes.
Cite This Study
Curtis et al. (2016) studied this question.