What question did this study set out to answer?

To analyze the sequence conservation, protein domain architecture, and genomic distribution of BTB domain-containing proteins across diverse eukaryotic lineages.

September 15, 2005Genome biologyOpen Access

Sequence and structural analysis of BTB domain proteins

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Authors

PSP.J. StogiosUniversity of Toronto GDGregory S. DownsWeatherford College JJJimmy JS JauhalUniversity of Toronto

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Implication

Comparative genomic analysis reveals structural conservation and diverse assemblies of BTB domain families in eukaryotes, highlighting adaptable protein-protein interaction mechanisms.

Key Points

To analyze the sequence conservation, protein domain architecture, and genomic distribution of BTB domain-containing proteins across diverse eukaryotic lineages.
Surveyed the genomic distribution, domain architecture, and sequence conservation of BTB proteins across 17 fully sequenced eukaryotic genomes.
Constructed a structural model of a BTB-Cul3 SCF-like E3 ubiquitin ligase complex using structural homology between Skp1 and the PLZF BTB homodimer.
Identified that BTB domains typically occur as single copies paired with distinct partner domains, showing lineage-specific expansions such as BTB-ZF and BBK in vertebrates, MATH-BTB in Caenorhabditis elegans, and BTB-NPH3 in Arabidopsis thaliana.
Demonstrated that the core BTB fold is structurally conserved despite divergent sequences, accommodating multimeric assemblies such as BTB dimers and T1 tetramers within Cul3 ubiquitin ligase complexes.

Cite This Study

Stogios et al. (2005) studied this question.

synapsesocial.com/papers/6a0fb468d8c5cf602efd0f38 https://doi.org/10.1186/gb-2005-6-10-r82

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Implication

Comparative genomic analysis reveals structural conservation and diverse assemblies of BTB domain families in eukaryotes, highlighting adaptable protein-protein interaction mechanisms.

Sequence and structural analysis of BTB domain proteins

Discussion

Member takes

Implication

Key Points

Cite This Study

Sequence and structural analysis of BTB domain proteins

Discussion

Member takes

Implication

Key Points

Cite This Study

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