Traditional and advanced electrocardiographic measures of autonomic function in the population-based KORA-F3 study

Figures

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  Fig. 1. Distribution of traditional HRV measures and of advanced markers of cardiac autonomic function. Histogram distribution of HRV-measures in our cohort. Red lines showing clinically established cut-offs. Green lines representing 5% and 95% percentile, blue lines representing 1% and 99% percentile where appropriate. Abbreviations: SDNN—Standard Deviation of the Normal-to-Normal interval; LF—Low Frequency; HF—High Frequency ratio; DC—Deceleration Capacity; PRD—Periodic Repolarization Dynamics

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  Fig. 2. Characterization of the reported measures by age. Scatter plot distributions of Mean heart rate, QTc, SDNN, LF/HF-ratio, DC, and PRD including a predicted regression line for the relation with age. Abbreviations: SDNN—Standard Deviation of the Normal-to-Normal interval; LF—Low Frequency; HF—High Frequency; DC—Deceleration Capacity; PRD—Periodic Repolarization Dynamics

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  Fig. 3. Propensity of clinically proposed cut-offs for the reported measures stratified by age and sex. For SDNN, DC, and PRD, relevant cut-off values have been proposed clinically. For LF/HF-ratio we used the median in lack of clinically established cut-off values. We present the propensity of these cut-off values for all parameters in our overall cohort (left panels). We also compare the propensity of these cut-off values in strata according to sex (second and third panels from the left), different age groups (mid panels) and Body mass index (BMI, right panel) with red illustrating the proportion of participants with potentially pathologic values. Abbreviations: SDNN—Standard Deviation of the Normal-to-Normal interval; LF—Low Frequency; HF – High Frequency; DC—Deceleration Capacity; PRD—Periodic Repolarization Dynamics; MI—Myocardial infarction

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  Fig. 4. Propensity of clinically proposed cut-offs for the reported measures stratified by comorbidities. For SDNN, DC, and PRD, relevant cut-off values have been proposed clinically. For LF/HF-ratio we used the median in lack of clinically established cut-off values. We present the propensity of these clinical cut-off values for all parameters in our overall cohort (left panels). We also compare the propensity of these cut-off values in strata of our cohort (three right panels). The cohort was stratified by hypertension status (left), intake of betablockers (middle), and prevalence of concomitant diagnoses of myocardial infarction, stroke, or diabetes mellitus (right). Abbreviations: SDNN—Standard Deviation of the Normal-to-Normal interval; LF—Low Frequency; HF—High Frequency; DC—Deceleration Capacity; PRD—Periodic Repolarization Dynamics; MI—Myocardial infarction