July 1, 2004DiabetesOpen Access

Enhanced Sarcolemmal FAT/CD36 Content and Triacylglycerol Storage in Cardiac Myocytes From Obese Zucker Rats

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Why the study?

Does FAT/CD36 relocation contribute to myocardial triacylglycerol accumulation and altered LCFA uptake in cardiac myocytes from obese Zucker rats?

Structured PICO

Does FAT/CD36 relocation contribute to myocardial triacylglycerol accumulation and altered LCFA uptake in cardiac myocytes from obese Zucker rats?

Population

Cardiac myocytes from lean and obese Zucker rats

Intervention

In vitro administration of insulin, oligomycin (contraction-mimetic agent), or sulfo-N-succinimidyloleate (FAT/CD36 inhibitor)

Comparator

Basal conditions and comparison between lean and obese rat myocytes

Outcome

Initial rate of long-chain fatty acid (LCFA) uptake, subcellular distribution of FAT/CD36, and LCFA metabolism (esterification into TAGs)surrogate

Permanent relocation of FAT/CD36 to the sarcolemma in cardiac myocytes of obese Zucker rats drives myocardial triacylglycerol accumulation and cellular insulin resistance.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Does not inform clinical targeting yet; leaves open FAT/CD36 inhibition for human myocardial steatosis.

Cite This Study

Coort et al. (2004) studied this question.

synapsesocial.com/papers/6a0fb7fd8090e499da6016ee https://doi.org/10.2337/diabetes.53.7.1655

View Full Paper

Ask AI

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Enhanced Sarcolemmal FAT/CD36 Content and Triacylglycerol Storage in Cardiac Myocytes From Obese Zucker Rats

Structured PICO

Discussion

Implication

Cite This Study

Enhanced Sarcolemmal FAT/CD36 Content and Triacylglycerol Storage in Cardiac Myocytes From Obese Zucker Rats

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider