July 1, 2004DiabetesOpen Access

Enhanced Sarcolemmal FAT/CD36 Content and Triacylglycerol Storage in Cardiac Myocytes From Obese Zucker Rats

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Why the study?

Does FAT/CD36 relocation contribute to myocardial triacylglycerol accumulation and altered LCFA uptake in cardiac myocytes from obese Zucker rats?

Population

Cardiac myocytes from lean and obese Zucker rats

Comparison

In vitro administration of insulin, oligomycin… vs Basal conditions and comparison between lean and…

Design

Preclinical

Authors

SCSusan L. CoortMaastricht University DHDanny M. HasselbainkJanssen (Netherlands)DKDebby P.Y. KoonenUniversity Medical Center Groningen

Discussion

Member takes

Implication

Does not inform clinical targeting yet; leaves open FAT/CD36 inhibition for human myocardial steatosis.

Structured PICO

Does FAT/CD36 relocation contribute to myocardial triacylglycerol accumulation and altered LCFA uptake in cardiac myocytes from obese Zucker rats?

Population

Cardiac myocytes from lean and obese Zucker rats

Intervention

In vitro administration of insulin, oligomycin (contraction-mimetic agent), or sulfo-N-succinimidyloleate (FAT/CD36 inhibitor)

Comparator

Basal conditions and comparison between lean and obese rat myocytes

Outcome

Initial rate of long-chain fatty acid (LCFA) uptake, subcellular distribution of FAT/CD36, and LCFA metabolism (esterification into TAGs)surrogate

Permanent relocation of FAT/CD36 to the sarcolemma in cardiac myocytes of obese Zucker rats drives myocardial triacylglycerol accumulation and cellular insulin resistance.

Cite This Study

Coort et al. (2004) studied this question.

synapsesocial.com/papers/6a0fb7fd8090e499da6016ee https://doi.org/10.2337/diabetes.53.7.1655

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Enhanced Sarcolemmal FAT/CD36 Content and Triacylglycerol Storage in Cardiac Myocytes From Obese Zucker Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Enhanced Sarcolemmal FAT/CD36 Content and Triacylglycerol Storage in Cardiac Myocytes From Obese Zucker Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider